Over the last few decades, bacteria, fungi, and viruses have become more difficult to eradicate. Increasingly, traditional antimicrobials and detergents are being “out smarted” by pathogenic microbials.

A new class of antimicrobials and decontamination strategies were desperately needed.

After a decade of research, BIOSAFE Defenses is set to revolutionize how disinfectants are viewed and used with the development of a new class of synthetic antimicrobials. Known as p-phenylene ethynylenes, these compounds are fundamentally different from traditional antimicrobials in that they are light-activated and deal broad-spectrum damage to pathogenic microbes in a detergent-like manner. So novel in fact, that Biosafe Defenses’ technology has secured 15 patents. View patent portfolio.

Our research has validated two key areas:

  • Oligomers’ compatibility with surfactants: We proved oligomers conferred numerous biocidal benefits, both sporicidal and fungicidal.
  • Polymers have the ability to attach to plastics, metals, glass, and textiles.

Today, BIOSAFE Defenses specializes in the synthesis and application of p-phenylene ethynylenes. Though they resemble traditional quarternary ammonium compounds, their unique pi-conjugated backbone provides enhanced antimicrobial properties. Under specific lighting conditions, these water-soluble compounds generate cell-damaging reactive oxygen species. These light-activated compounds have, in university studies, shown to have numerous advantages:

  • Predictive kill window
  • Broad-spectrum compounds rapidly kill antibiotic-resistant strains of bacteria
  • Greater capacity for biofilm eradication than antibiotics
  • Better suited for treating textiles
  • Compatible with detergents
  • Highly effective against viruses and fungal yeast.
  • Safe to use

BIOSAFE Defenses’ compounds are inexpensive, shelf-stable, non-toxic to mammalian cells, and can be surface grafted or incorporated into liquid solutions (soaps, detergents, sprays), incorporated into plastics and resins, impregnated into fabrics, and electrospun into fibers. The polymers and oligomers can be synthesized to varying lengths and made with different side chains, leading to tunable properties so that, for example, some are leachable, some are not, some are more active in light while some are extremely active in the dark. The compounds may also be used to control microbial adhesion (biofilm).

Learn more. Contact us now.

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